FAQ

Applications

Which reference laboratories exist?
Answer:
NBS: R. Fingerhut, Childrens Hospital Zürich, Switzerland
TDM: U. Duthaler, University Basel, Switzerland
Forensic: W. Weinmann, University Bern, Switzerland
Haematocrit Research: C. Stove, University Ghent, Belgium
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Are there commercial reagent kits available?
Answer: This depends on the field of application, please contact dbs@camag.com for detailed information.
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LC-MS system

Which LC-MS brand is compatible with the DBS-MS 500?
Answer: The DBS-MS 500 can be run with all common LC-MS brands. The Chronos software communicates with Shimadzu (Labsolutions), Agilent (MassHunter, Chemstation, EZChrom), Sciex (Analyst), Waters (MassLynx), Brucker (PACER) and Thermo (Xcalibur, QuanLab Forms).
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What sensitivity is required?
Answer: This strongly depends on the target molecule concentration, please contact a CAMAG scientist for support.
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Consumables

Which DBS or DMS cards can I use?
Answer: The gripper of the DBS-MS 500 is constructed to handle any cards that share the same format as 903, 226 or TFN cards. 84.67 mm × 53.2 mm (w × h).
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Technology

How is the patient data recognized and linked with the report?
Answer: The optical card recognition unit (OCR) scans the barcode of each card prior to extraction and saves the information together with the analysis results.
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What is the price range of the DBS-MS system?
Answer: Please contact our sales department at sales@camag.com for detailed information on pricing.
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What is the recommended solvent for the internal standard?
Answer: It is recommended to use a solvent that dries relatively fast (e.g. methanol) to ensure that the sample is dry prior to extraction.
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How is the internal standard (IS) applied to the sample?
Answer: The internal standard (IS) is applied through the integrated precision spraying device prior to extraction. Different drying times can be chosen within the Chronos software. The introduction of the IS to the sample just before the extraction enables the compensation of analyte recovery by creating the most similar processing conditions for both analyte and IS.
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What is the size of the extraction area?
Answer: The standard extraction head has a 4 mm diameter.
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How is the extraction process and analyte recovery in the DBS-MS 500 optimized?
Answer: The specially designed extraction unit allows perfect sealing of the extraction area and prevents solvent leaks. The extraction time, the solvent volume and its flow can be adjusted manually. The method optimization can be performed according to standard methods (educated guess) or an optimization protocol, which was developed by CAMAG.
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How does the DBS-MS 500 system solve the problem of carry-over?
Answer: After each extraction, a designated wash station cleans all parts which were in contact with the DBS card. Studies have shown that there is absolutely no carry-over with this specially designed rinsing system.
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What are the system’s dimensions?
Answer: The DBS-MS 500 size is 110 × 80 × 60 cm (w × d × h). Additional space of 10 cm for ventilation and height of 30 cm for solvent bottle placement should be kept in mind.
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Is there a possibility to run the system under UPLC conditions?
Answer: Yes, the system comes with UPLC parts.
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How does the DBS-MS 500 communicate with the MS?
Answer: The communication is managed via the master Chronos software, which controls all systems. The DBS-MS 500 also communicates with any external device through an Ethernet connection, which is able to give “start”, “contact” or “closure” signals.
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